Oxidative phosphorylation occurs

  • ATP synthase
  • coenzyme Q (CoQ)
  • chemiosmotic coupling
  • cristae
  • cytochrome b-c complex
  • cytochrome c
  • cytochrome oxidase
  • electron transport chain (ETC)
  • F0 subunit
  • F1 subunit
  • intermembrane space
  • matrix
  • NADH dehydrogenase
  • oxidative phosphorylation
  • proton motive force (PMF)
  • redox pair
  • redox potential
  • respiratory chain
  • succinate dehydrogenase
  • ubiquinone

This tutorial will describe the mechanisms involved in the synthesis of ATP during cellular respiration. The final stage of cellular respiration occurs in the mitochondria, where the reduced electron carriers (NADH and FADH2) donate their electrons to oxygen via an electron transport chain. As the electrons travel, a hydrogen electrochemical gradient is generated across one of the two mitochondrial membranes. The energy of this electrochemical proton gradient is used to synthesize ATP.

By the end of this tutorial you should know:

  • The nature of the chemiosmotic coupling of electron transport and ATP synthesis
  • The features of a mitochondrion
  • The meaning of redox potential and how it determines the flow of electrons
  • The mechanisms of electron transport (including the role of the reduced electron carriers NADH and FADH2, and oxygen)
  • How the hydrogen electrochemical gradient is formed
  • How the hydrogen electrochemical gradient is used to synthesize ATP
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IkB alpha, phosphorylated (Tyr305) (NF-kappa-B Inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major Histocompatibility Complex Enhancer-binding Protein MAD3, NFKBIA, IKBA, MAD3, NFKBI), I2500-05G-100ul
BISS (United States Biological)
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